With the increasingly temperature, the hand-foot-and-mouth disease (HFMD) has entered a high incidence period. It specifically happens between 6 months and 6 years of children. Among the 2018 National Infectious Diseases Report, it ranked first with 2.376 million cases. Professor Zeng Guang, chief epidemiologist of China CDC, once said: the transmission coefficient of HFMD is three times of that of COVID-19.